Dog Poisoning Diseases –  Organophosphorus compound poisoning

Dog Poisoning Diseases – Organophosphorus compound poisoning

Organophosphorus compound poisoning

Cause

Organophosphorus compounds can enter the dog’s body through the digestive tract, respiratory tract or skin and cause poisoning. For example, if you accidentally eat food spread with organophosphorus pesticides, or drink contaminated ground water near the spraying area; when preparing or spreading organophosphorus pesticides. The scattered powder or mist of the liquid medicine contaminates the kennel and food nearby or downwind, and is licked by the dog. Or the dog is poisoned by inhaling the aerosol containing the above-mentioned medicament while training, working or playing in the downwind direction ; improper medication. Such as the abuse of organophosphorus pesticides to treat ectoparasites. Or overdose trichlorfon to get rid of gastrointestinal parasites.

Diagnosis points

Due to the different toxicity, intake, route of poisoning, and the health of the body of various organophosphorus pesticides, the clinical manifestations and development of poisoning are also diverse. But most of them take the acute course, and the sick dog suddenly develops the disease within a few hours after inhaling, cannibalizing or contaminating the skin. At the beginning of the illness, dogs were excited and restless. Muscle spasms generally start from the eyelids and facial muscles, and quickly extend to the neck, trunk and even the muscles of the whole body, with slight tremors. In severe cases, convulsions, muscle clonus of the limbs, the sick dog steps frequently, and swim-like movements when lying horizontally. Pupils diminish and become linear in severe cases. Sick dogs salivate, appetite is greatly reduced or abolished, and abdominal pain. The bowel sounds are high and loud, continuous, unceasing watery stools, and even incontinence of bowel movements. In the later stage of severe illness, bowel sounds weaken or even disappear. Sweat all over the body, especially around the chest, perineum and scrotum. The body temperature rises, and it is obviously difficult to breathe. The heartbeat was rapid, the pulse was weak, the conjunctiva became cyanotic, and he died of suffocation.

According to the etiology and clinical symptoms, the diagnosis can be basically made.

Treatment

Application of atropine sulfate intravenously. The dosage can be 1 mg/kg body weight. If the symptoms are not relieved after 1 to 2 hours, the medication can be repeated. When the dog has dry mouth, dilated pupils, steady breathing, and rapid heartbeat, the so-called “atropine”, the medication can be stopped. Since atropine cannot revive cholinesterase that has been combined with organophosphate, it is best to use it in conjunction with pralidoxime and pralidoxime for severe cases. Phosphoridine iodide (Pymer) and Phosphoridine chlorate (Pyram) are cholinesterase resurgents. They have a strong phosphorophilic effect and can take away the phosphoryl group bound to the cholinesterase. Restore the hydrolysis ability of the enzyme, and at the same time can make the organophosphate into the human body lose toxicity . Therefore, it is a remedy for acute organophosphate poisoning. However, it has a poor effect on malathion and other poisonings, and must be used with atropine at the same time. The dosage of pralidoxime iodide is 20 mg/kg body weight-time. For intravenous injection. The dosage of pralidoxime chloride is 20 mg/kg body weight·time. The rejuvenating effect of diphosate on cholinesterase activity is better than that of pralidoxime, and it can pass through the blood-brain barrier and has atropine-like effects. The dosage is 15-30 mg/kg body weight·time. Sick dogs poisoned by zinc phosphide rodent poison can be used to induce vomiting, gastric lavage, and laxatives to promote the elimination of poisons. For vomiting, 0.2% to 0.5% copper sulfate solution can be administered, gastric lavage can be used with 0.1% potassium permanganate solution 50-100 ml, sodium sulfate can be administered for laxatives, and symptomatic therapies such as rehydration, cardiotonia, and diuresis can be used. For patients with pulmonary edema, dexamethasone 1 mg/kg body weight can be injected intravenously or intramuscularly.

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